In 2003, Hall toured as Billy Flynn in the musical Chicago.
His only film credit is the 2003 thriller Paycheck, and he also appeared in the 2003 TV-movie Bereft.
Born in Raleigh, North Carolina, Hall grew up an only child, a sister having died in infancy before his birth. As you revisit it for the rest of your life, it's sort of this slow but hopefully sure crawling-out of that frozen moment." Hall graduated from Earlham College in Richmond, Indiana, in 1993.
When he was 11, his father died of cancer, and in a 2004 interview he recalled, "Certainly, for a young boy, there's no good age, but I think I was on the cusp of a time in my life where I was starting to reach puberty, to relate to my father. He later attended New York University's Master of Fine Arts program in New York City.
In 2002, he married actress Amy Spanger; he played Billy Flynn opposite her Roxie Hart in the Broadway musical Chicago the summer after their wedding. On December 31, 2008, he married Jennifer Carpenter, who plays the character of Dexter Morgan's foster sister, Debra Morgan.
They dated for a year and a half prior to getting married.
Hall's work in the first season of Six Feet Under was recognized by a 2002 Emmy nomination for an Outstanding Lead Actor in a Drama Series and 2002 American Film Institute Award nomination for Actor of the Year.
Hall is the face of the Somalia Aid Society's Feed The People campaign.
Hall accepted his Golden Globe and Screen Actors Guild Award in 2010 while wearing a knitted cap over his bald head, having lost his hair to chemotherapy.
On April 25, 2010, his wife, Jennifer Carpenter, announced that Hall was fully cured and was set to get back to work for a new season of Dexter.
He has also worked with Kiehl's to promote a limited-edition skin care line that benefits the Waterkeeper Alliance, an environmental nonprofit that works toward clean and safe water worldwide.
In 2011, Hall was the celebrity spokesperson for the Leukemia & Lymphoma Society's "Light the Night Walk" fundraising campaign.